VancoPro brings evidence-based vancomycin pharmacokinetics to iOS — Bayesian MAP, Sawchuk–Zaske, AUC24 targeting, and real-time dose optimization for pharmacists and clinicians.
Built on peer-reviewed pharmacokinetic equations and the 2020 ASHP/IDSA/SIDP vancomycin guidelines. No guesswork — just evidence-based calculations.
Steady-state IV intermittent infusion model with Cockcroft–Gault CrCl estimation. Calculates Vd, ke, half-life, peak, trough, and AUC24 from patient-specific parameters.
Input 1–2 measured serum levels to update population PK priors with Maximum A Posteriori Bayesian estimation. Refines individual CL and Vd for more accurate dosing.
Two-level Sawchuk–Zaske analysis for patient-specific pharmacokinetic parameter estimation. Calculates individualized CL, Vd, and ke from measured peak and trough levels.
Target AUC24/MIC 400–600 mg·h/L per 2020 ASHP/IDSA/SIDP guidelines, or traditional trough-based monitoring. Visual band indicators show therapeutic, subtherapeutic, and supratherapeutic ranges.
Generates multiple dose/interval combinations ranked by target attainment. Supports back-calculation from desired AUC24 or trough. Applies RxToDose infusion time rules automatically.
Save and revisit previous patient calculations with full PK results. Quickly compare regimens across visits or load a prior case to adjust parameters.
Track SCr changes over time with automatic rate-of-change analysis. Alerts for rapidly rising creatinine (potential AKI) where steady-state PK assumptions may not hold.
Interactive concentration-time curve visualization showing peak, trough, and therapeutic window across multiple dosing intervals. Exportable results for clinical documentation.
A streamlined four-step workflow designed for clinical efficiency.
Input age, sex, actual body weight, height, and serum creatinine. VancoPro calculates CrCl via Cockcroft–Gault and estimates population-based vancomycin clearance.
Supports IBW/ABW/AdjBW selection, obese patient adjustments, and optional renal trend tracking with two SCr values.
Enter the proposed dose and interval, or let the dose optimizer suggest regimens. Choose between AUC24 (400–600) or trough (15–20 mg/L) monitoring targets.
Infusion time is auto-calculated using RxToDose rules or manually overridden. Supports Q8h, Q12h, Q24h, and custom intervals.
For patients with measured drug levels, enter 1–2 serum concentrations with collection times to enable Bayesian MAP or Sawchuk–Zaske individualization.
Accepts pre-dose trough, post-infusion peak, or any random level with time since infusion start.
Instantly view patient-specific Vd, CL, ke, half-life, Cmax, Ctrough, AUC24, and AUC/MIC. Color-coded band indicators flag therapeutic vs. out-of-range values.
Concentration-time chart visualizes the full dosing interval. Share or save results to patient history.
Every calculation in VancoPro is derived from established pharmacokinetic literature and current clinical guidelines.
| Parameter | Target Range | Guideline |
|---|---|---|
| AUC24/MIC | 400–600 mg·h/L | ASHP 2020 |
| AUC24 (no MIC) | 400–600 mg·h/L | ASHP 2020 |
| Trough (serious) | 15–20 mg/L | Traditional |
| Trough (general) | 10–15 mg/L | Traditional |
| Peak (general) | 25–40 mg/L | Reference |
Optimize vancomycin regimens at the bedside. Integrate Bayesian individualization with measured levels for complex patients.
Quick dose verification and AUC24 target assessment without leaving the patient's side. Supports shared decision-making.
Learn PK principles through hands-on calculation. Visualize how patient parameters affect drug exposure and dosing.
Manage complex patients with renal impairment, obesity, or AKI. Renal trend monitoring flags unstable kidney function.
VancoPro is intended for educational and reference purposes only. All calculations must be verified by a licensed healthcare professional before clinical application. VancoPro does not constitute medical advice and is not a substitute for clinical judgment. Always consult current institutional protocols and guidelines.
All features fully unlocked at no cost. Optional $9.99/year VancoPro Pro subscription removes ads for an uninterrupted experience.